Gallstones

The forming of gallstones is a common problem for people with pyruvate kinase deficiency and may result in biliary colic.
What’s the link between gallstones and Pyruvate Kinase Deficiency?
Gallstones (also called cholelithiasis) are formed when there is a high level of a particular substance in the bile fluid. In patients with hemolytic anemia, there is a high concentration of bilirubin and calcium in the bile fluid and the concentration of the bile acids decreases. The high concentrations of bilirubin and calcium  lead to an oversaturation of calciumbilirubinate in the bile. This calciumbilirubinaat precipitates and forms microscopic gallstones. As the saturation persists, gallstones grow into mature black pigment stones. These black pigment gallstones are very typical for patients with hemolytic anemia. They are not the same kind of gallstones as the brown pigment stones and cholesterol stones.
“When I was 16 my upperright tummy started to hurt a lot. Especially after eating peanuts. When they removed my gallblader it was very inflamed and the gallstone was the size and color of a giant meatball”
Female, 40 years
Gallbladder removal
To avoid gallstones, many patients with PKD have their gallbladder removed through laparoscopic surgery, which is called “cholecystectomy”. Mostly this happens in combination with the removal of the spleen.
“I had my gallbladder removed with laparoscopic surgery when I was 25. Up until then I had several smaller and bigger biliary colics a year and the pain used to hit me just below the chest”
Female, 28 years
Disclaimer: This article is written by patients and is meant for basic informational purposes only. It is not intended to serve as medical advice, substitute for a doctor's appointment or to be used for diagnosing or treating a disease. Users of this website are advised to consult with their physician before making any decisions concerning their health. For details see our full disclaimer.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s