There is still a lot unknown about Pyruvate Kinase Deficiency, because patients are rare and there hasn’t been much research. Medical practitioners are trying to gather more information and experiences, to learn more about the possible complications of Pyruvate Kinase Deficiency.
“Rare complications include; aplastic crisis following parvovirus infections, kernicterus, chronic leg ulcers, acute pancreatitis secondary to biliary tract disease, splenic abscess, spinal cord compression by extramedullary haematopoietic tissue and thromboembolic events”
Tanaka & Zerez, 1990; Pincus et al, 2003
Some patients complain about muscle and joint pain, stomach aches and other symptoms, but till now it is not yet proven that this has anything to do with Pyruvate Kinase Deficiency. It also seems that persons with Pyruvate Kinase Deficiency have a higher risk for Osteoporosis.
How Pyruvate Kinase Deficiency could be linked to osteoporosis
The bone marrow situated in the bones is working much harder to produce all the bloodcells that are needed. For that reason the bone marrow is extending in volume. Each person might have a different place where the overgrown bones are situated. For many people the bone marrow in the head is growing faster resulting in frontal bossing.
Due to the harder working bone marrow, people with Pyruvate kinase deficiency often need extra Calcium to support the bones to keep solid and prevent getting Osteoporosis.
For some reason many people with Pyruvate Kinase deficiency also have lower vitamine D levels as well, perhaps because the body needs more vitamines to produce the extra bloodcells. Low vitamine D levels can cause Osteoporosis as well, so it is very important to keep the vitamine levels up.
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